2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-137396
    6β-Hydroxy Eplerenone 209253-80-5 98%
    6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251). 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV).
    6β-Hydroxy Eplerenone
  • HY-13764A
    dl-Tetrandrine 23495-89-8 98%
    dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca2+ influx with an IC50 value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal.
    dl-Tetrandrine
  • HY-138019
    SP-8008 2088247-61-2 98%
    SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC50 of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation.
    SP-8008
  • HY-138947
    KB-R7943 182004-64-4 98%
    KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC50 value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.
    KB-R7943
  • HY-139067
    25(S)-27-Hydroxy cholesterol 56845-83-1 98%
    25(S)-27-Hydroxy cholesterol is a metabolite of CYP27A1 mediated cholesterol hydroxylation. 25(S)-27-Hydroxy cholesterol inhibits melanoma cell proliferation.
    25(S)-27-Hydroxy cholesterol
  • HY-139117
    6,2′,4′-Trimethoxyflavone 720675-90-1 98%
    6,2′,4′-Trimethoxyflavone is an AhR antagonist and has failed to show effective protective effects against cerebral ischemia/reperfusion injury in Sprague-Dawley rats.
    6,2′,4′-Trimethoxyflavone
  • HY-139134
    S-2E 155730-92-0 98%
    S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.
    S-2E
  • HY-13927R
    Acetildenafil (Standard) 831217-01-7
    Acetildenafil (Standard) is the analytical standard of Acetildenafil. This product is intended for research and analytical applications. Acetildenafil is a Sildenafil (HY-15025) analogue, a phosphodiesterase 5 (PDE5) inhibitor. Acetildenafil can be isolated from herbal products.
    Acetildenafil (Standard)
  • HY-139486
    AM-8123 2049973-02-4 99.89%
    AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease.
    AM-8123
  • HY-13955R
    Telmisartan (Standard) 144701-48-4
    Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
    Telmisartan (Standard)
  • HY-139727
    S(-)-Bisoprolol 99103-03-4 98%
    S(-)-Bisoprolol is a S(-)-enantiomer of Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.
    S(-)-Bisoprolol
  • HY-139797
    SCH 47896 142621-29-2 98%
    SCH 47896 is a phenolic derivative of SCH39370 (HY-139803), a potent specific inhibitor of metalloendopeptidase (NEP). SCH 47896 can be used for the research of cardiovascular disease, such as hypertension.
    SCH 47896
  • HY-139801
    Indolapril hydrochloride 80828-32-6 98%
    Indolapril hydrochloride (CI-907) is an orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. Indolapril hydrochloride is highly specific in suppressing the contractile or pressor responses to Angiotensin I. Indolapril hydrochloride is a potent antihypertensive agent.
    Indolapril hydrochloride
  • HY-139803
    SCH-39370 115406-23-0 98%
    SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
    SCH-39370
  • HY-139876
    APJ receptor agonist 3 2759159-56-1 98%
    APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.
    APJ receptor agonist 3
  • HY-139938
    (±)11(12)-EET methyl ester 90693-45-1 98%
    (±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis.
    (±)11(12)-EET methyl ester
  • HY-139993
    HIF-PHD-IN-2 2711720-45-3 98%
    HIF-PHD-IN-2 (compound 25) is a potent PHD inhibitor with IC50s of <100 nM for PHD1, PHD2 and PHD3, respectively.
    HIF-PHD-IN-2
  • HY-141612
    Pyrrolidino PAF C-16 91021-63-5 98%
    Pyrrolidino PAF C-16 is a platelet activating factor ( PAF ) analogue that has hypohematic effects.
    Pyrrolidino PAF C-16
  • HY-14182S
    Vernakalant-d6 hydrochloride 866455-16-5 98%
    Vernakalant-d6 (hydrochloride) is deuterium labeled Vernakalant.
    Vernakalant-d6 hydrochloride
  • HY-142019
    Tanshinol borneol ester 1623012-10-1 98%
    Tanshinol borneol ester, an angiogenesis stimulator, promoted multiple key steps of angiogenesis through Akt and MAPK signalling pathways. Tanshinol borneol ester has anti-ischemic and anti-atherosclerosis activities.
    Tanshinol borneol ester
Cat. No. Product Name / Synonyms Application Reactivity